Pre-Assessment

Name
Which of the following best represents your profession?
What is your primary specialty?
1. What is the presumed primary mechanism underlying ARIA related to amyloid targeting therapy?
2. A 64-year-old APOE ε4 carrier is receiving ATT and being monitored for ARIA. Which MRI sequence would you use to detect for ARIA-H?
3. A 68-year-old patient with mild cognitive impairment on ATT undergoes routine MRI. FLAIR imaging reveals new focal/asymmetrical hyperintense cortical and subcortical regions without associated restricted diffusion. There is no evidence of infarction or mass effect. What do you report to the referring neurologist?
4. The MRI of a 57-year-old patient on ATT reveals new FLAIR hyperintensities involving multiple lobes, each < 10 cm, without significant mass effect. Interpret the MRI findings.
5. The referring neurologist asks for clarification on an MRI with possible ARIA-E for a patient who had been experiencing a headache while on ATT. What is the key safety consideration?
6. Why is it important to utilize all resources, including medical alert tools, for members of the interdisciplinary care team who are managing patients receiving an ATT?
7. How confident are you in your ability to monitor ARIA among patients with Alzheimer's disease who are receiving ATTs?
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